Biggles Flies Again is a collection of short stories that link together to form what almost reads like a full novel. Starting in Guiana, and obtaining an aircraft in lieu of missing salary payments, the story follows the team's adventures as they take a roundabout route back to England.

The adventures find them searching for Gold on the orinoco, rescuing a woman from Peruvian bandits, helping another escape from the law, searching for rare orchids, pearls (complete with Capt Johns obligatory giant octupus), shipwrecks, the list goes on. The journey takes them across the Pacific, to PNG, Australia, and then home along the asian route.

This book also marks the introduction of Li Chi, a Chinese-Malayan smuggler who Biggles unknowingly saves from arrest. His act is not forgotten with Li Chi and Biggles teaming up later to thwart the Japanese in Biggles Delivers the Goods.